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Publications

April 2023

Linoleic acid potentiates CD8+ T cell metabolic fitness and antitumor immunity

April 2025

Activated T cells break tumor immunosuppression by macrophage re-education

Massimiliano Mazzone

March 2025

A functional single-cell metabolic survey identifies Elovl1 as a target to enhance CD8+ T cell fitness in solid tumours

Massimiliano Mazzone

June 2024

Nucleotide metabolism in cancer cells fuels a UDP-driven macrophage cross-talk, promoting immunosuppression and immunotherapy resistance

Massimiliano Mazzone

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Posters

December 2022

Targeting the bicarbonate transporter SLC4A4 overcomes immunosuppression and immunotherapy resistance in pancreatic cancer

Massimiliano Mazzone

January 2022

Plexin-A4 Mediates Cytotoxic T-cell Trafficking and Exclusion in Cancer

Massimiliano Mazzone

May 2018

A rationally designed NRP1-independent superagonist SEMA3A mutant is an effective anticancer agent

Enrico Giraudo and Guido Serini

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Our approach aims at reprogramming the solid tumor microenvironment to unlock the full potential of cancer immunotherapy.

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Join Lever Bio in advancing promising research and driving innovative drug development in the immuno-oncology field

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