Pipeline

Our compounds target components of the solid tumor microenvironment to foster anti-cancer immune response enhancing the recruitment, activation and sustained function of cytotoxic T lymphocytes against solid tumors.

Our approach aims at reprogramming the solid tumor microenvironment to unlock the full potential of cancer immunotherapy.

SLC4A4

LVB 003

SCL4A4

is a bicarbonate transporter that induces bicarbonate uptake by cancer cells and increases TME acidity.

DP1/2

sustain TAMs immunosuppressive phenotype and impair CD8 T cell functions by prostaglandin D2 (PGD2) signaling.

LVB-004

DP1/2

P2Y6

LVB-005

P2Y6

Cytidine deaminase (CDA) is an enzyme of the pyrimidine salvage pathway that is involved in extracellular release of UTP and UDP. CDA-positive cancer cells recruit P2Y6-positive macrophages and sustain their immunosuppressive activity via UDP and UTP release.

Linoleic acid (LA)

is a major positive regulator of cytotoxic T lymphocyte activity by improving metabolic fitness, preventing exhaustion and stimulating a memory-like phenotype with superior effector functions.